Lack of what vitamin can cause Rickets?

Rickets is a disease that primarily affects bone development in children. It is caused by a deficiency of vitamin D, which plays a crucial role in the regulation of calcium and phosphate in the body, both of which are essential for the formation of strong and healthy bones. When there is not enough vitamin D, the body cannot absorb adequate amounts of calcium and phosphorus from the diet, leading to weakened bones that are soft and prone to deformities, characteristic of rickets.

While vitamin A, vitamin K, and vitamin E are important for various bodily functions, such as vision, blood clotting, and antioxidant protection respectively, they do not have the direct impact on bone mineralization that vitamin D has. Thus, the connection between vitamin D deficiency and the development of rickets makes it the correct answer.